Health Care-Illness: Difference between revisions

Latest revision as of 10:43, 13 March 2022

America's Vaccine Rollout Disaster

New York Mag Dec 30 2020 David Wallace-Wells

It’s happening all over again. For months, Americans who despaired about the country’s coronavirus-suppression efforts looked desperately to the arrival of a vaccine for a kind of pandemic deliverance. Now that it has arrived, miraculously fast, we are failing utterly to administer it with anything like the urgency the pace of dying requires — and, perhaps most maddeningly, failing in precisely the same way as we did earlier in the year. That is, out of apparent, near-total indifference.

Blood Clots Linked to AstraZeneca Vaccine Stem From Rare Antibody Reaction

NYT By Denise Grady April 9, 2021

Scientific teams from Germany and Norway found that people who developed the clots after vaccination had produced antibodies that activated their platelets, a blood component involved in clotting. The new reports add extensive details to what the researchers have already stated publicly about the blood disorder.

Excess mortality during the Coronavirus pandemic (COVID-19)

Our World Data

The chart here shows excess mortality during the pandemic for all ages using the P-score.6 To see the P-scores for other countries click  Add country on the chart.

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

[https://www.nejm.org/doi/full/10.1056/NEJMc2031364 New England Journal of Medicine 12/03/20

Although most immunocompromised persons effectively clear SARS-CoV-2 infection, this case highlights the potential for persistent infection5 and accelerated viral evolution associated with an immunocompromised state.

Extraordinary Patient Offers Surprising Clues To Origins Of Coronavirus Variants

NPR 2/02/21 MICHAELEEN DOUCLEFF

The sequences showed Li and his team that the virus was changing very quickly inside the man's body. The virus wasn't picking up just one or two mutations at a time. But rather, it acquired a whole cluster of more than 20 mutations. Scientists had never seen SARS-Cov-2 mutate so quickly during the whole pandemic.

Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection

JAMA Network Saurabh Rajpal, MBBS, MD1; Matthew S. Tong, DO1; James Borchers, MD, MPH1; et alKarolina M. Zareba, MD1; Timothy P. Obarski, DO1; Orlando P. Simonetti, PhD1; Curt J. Daniels, MD1 9/11/20

Of 26 competitive athletes, 4 (15%) had CMR findings suggestive of myocarditis and 8 additional athletes (30.8%) exhibited LGE without T2 elevation suggestive of prior myocardial injury. COVID-19–related myocardial injury in competitive athletes and sports participation remains unclear.

'Toxic Individualism': Pandemic Politics Driving Health Care Workers From Small Towns

NPR 12/29/20 Frank Morris

Rural hospitals were in deep trouble before the pandemic. Morgan says 132 of them have closed since 2010. COVID-19 made matters worse. The surge of desperately sick and highly contagious patients stopped hospitals from doing the lucrative elective outpatient procedures that keep them in business. Their small staffs have been run ragged. And the pandemic has filled the air with vitriol against medical expertise.

More than a quarter of all the public health administrators in Kansas quit, retired or got fired this year, according to Vicki Collie-Akers, an associate professor of population health at the University of Kansas. Some of them got death threats. Some had to hire armed guards.

Hunting for 'Disease X'

Sam Kiley Tue December 22, 2020

Humanity faces an unknown number of new and potentially fatal viruses emerging from Africa's tropical rainforests, according to Professor Jean-Jacques Muyembe Tamfum, who helped discover the Ebola virus in 1976 and has been on the frontline of the hunt for new pathogens ever since.

"We are now in a world where new pathogens will come out," he told CNN. "And that's what constitutes a threat for humanity."

As a young researcher, Muyembe took the first blood samples from the victims of a mysterious disease that caused hemorrhages and killed about 88% of patients and 80% of the staff who were working at the Yambuku Mission Hospital when the disease was first discovered.

A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged

A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged Elemental Thomas Smith Aug 31·2020 8 min read

A closer look at the Bradykinin hypothesis

Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week.

According to the team’s findings, a Covid-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose, (The receptors, which the virus is known to target, are abundant there.) The virus then proceeds through the body, entering cells in other places where ACE2 is also present: the intestines, kidneys, and heart. This likely accounts for at least some of the disease’s cardiac and GI symptoms.

The True Coronavirus Toll in the U.S. Has Already Surpassed 200,000

Across the United States, at least 200,000 more people have died than usual since March, according to a New York Times analysis of estimates from the Centers for Disease Control and Prevention. This is about 60,000 higher than the number of deaths that have been directly linked to the coronavirus.

Smallpox and other viruses plagued humans much earlier than suspected

The death date of smallpox is clear. After killing more than 300 million people in the twentieth century, it claimed its last victim in 1978; two years later, on 8 May 1980, the World Health Assembly declared that the variola virus, which causes smallpox, had been eradicated. But the origins of this devastating virus are obscure. Now, genetic evidence is starting to uncover when smallpox first started attacking people.

Humans as far back as AD 600 carried variola, an international research team reported this week1 after years of fishing for viral DNA in ancient human remains. The analysis also implies that the virus was circulating in humans even earlier: at least 1,700 years back, in the turbulent period around the fall of the Western Roman Empire, when many peoples were migrating across Eurasia.

Inside the body, the coronavirus is even more sinister than scientists had realized

Researchers exploring the interaction between the coronavirus and its hosts have discovered that when the SARS-CoV-2 virus infects a human cell, it sets off a ghoulish transformation. Obeying instructions from the virus, the newly infected cell sprouts multi-pronged tentacles studded with viral particles.
These disfigured zombie cells appear to be using those streaming filaments, or filopodia, to reach still-healthy neighboring cells. The protuberances appear to bore into the cells’ bodies and inject their viral venom directly into those cells’ genetic command centers — thus creating another zombie.

We Have No Idea If Covid Immune Responses Fall Off Rapidly in Cases Where There Is A Full Response!

We barely understand how the immune system works, actually, that isn’t completely accurate, we know parts of it.  We know that a full response involves numerous cell types.  Making antibody isn’t the end-all and be-all of the immune response.  As I wrote above, long-term immunity requires T and other types of cells.  We don’t even fully understand how long term anti-body responses work, completely.  What triggers are necessary to get anti-body production upon reexposure?  None of these studies are looking at the immune responses of the folks they are examining, they are looking at one aspect of a very complex system and drawing huge conclusions about the importance of the work.

COVID-19 Antibody Response Drops in 3 Months According to Kings College London Report in Review

In the first longitudinal study of its kind, scientists analysed the immune response of more than 90 patients and healthcare workers at Guy’s and St Thomas’ NHS foundation trust and found levels of antibodies that can destroy the virus peaked about three weeks after the onset of symptoms then swiftly declined.

I'm a physiotherapist. Seeing the impact of Covid on survivors will haunt me forever

I’ve never seen anything like coronavirus before. Recovering will be a Herculean task for patients, but we are here to help.
But never have I seen the cracked-glass effect on lung CT scans like those of Covid-19 patients. I have stared at them wondering where the breath is coming from, worrying if they will be able to conjure up the respiratory effort to sit, stand, step, move, live. Those scans will skulk in the depths of my brain for the rest of my days.

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

| Nature Published: 18 June 2020

These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.

@@ Line 1: / Line 1: @@
-=====The Rabbit Outbreak A highly contagious, often lethal animal virus arrives in the United States=====
+{{#seo:
-[https://www.newyorker.com/magazine/2020/07/06/the-rabbit-outbreak?utm_source=nl&utm_brand=tny&utm_mailing=TNY_Daily_063020&utm_campaign=aud-dev&utm_medium=email&bxid=5ef586acfda7562feb3d736e&cndid=61512174&hasha=f0e57389b5b6ce947e27301c632cb161&hashb=aeac0b5ca6f36cc0019dc8d94ae23514280b8daa&hashc=0c33721abf404e89835e29b0b03b7c348ebcdc56eb2922e714366c4e01e510ad&esrc=bouncexmulti_first&utm_term=TNY_Daily&fbclid=IwAR3IoF7jdSJloWxipgLZPMB45Hr2KtgOAgTXijqGKk89JOfxT1ePGLBz3SQ  The New Yorker June 2020]
+|title=Category Health Care-Illness
- One of the lagoviruses of the family Caliciviridae causes a highly contagious illness called rabbit hemorrhagic disease. RHD is vexingly hard to diagnose. An infected rabbit might experience vague lethargy, or a high fever and difficulty breathing, or it might exhibit no symptoms at all. Regardless of the symptoms, though, the mortality rate for RHD can reach a gloomy hundred per cent. There is no treatment for it. The virus’s ability to survive and spread is uncanny. It can persist on dry cloth with no host for more than a hundred days; it can withstand freezing and thawing; it can thrive in a dead rabbit for months, and on rabbit pelts, and in the wool made from Angora-rabbit fur, and in the rare rabbit that gets infected but survives. It can travel on birds’ claws and flies’ feet and coyotes’ fur. Its spread has been so merciless and so devastating that some pet owners have begun referring to it as “rabbit Ebola.”
+|description=Curated news selected for its relevance, longevity and non-prescriptive content.
+|keywords=Covid,custom search engine,free classified ads,bradykinin hypothesis immunological,Immune Responses
+|image=Covid Brandkini.jpeg
+|image_width=300
+|image_height=200
+}}
+[[File:Covid deaths vs excess deaths US.jpg|left|thumb|US Worldometer COVID Deaths vs Our World Data Excess deaths.]]
+=====America's Vaccine Rollout Disaster=====
+[https://nymag.com/intelligencer/article/americas-vaccine-rollout-disaster.html?fbclid=IwAR0NWb_tmKS7Y8O_GbdXTjFaEF-77VIUbJTvkYq38GmAz8U-XsS1o-U8PlU  New York Mag Dec 30 2020  David Wallace-Wells]
+It’s happening all over again. For months, Americans who despaired about the country’s coronavirus-suppression efforts looked desperately to the arrival of a vaccine for a kind of pandemic deliverance. Now that it has arrived, miraculously fast, we are failing utterly to administer it with anything like the urgency the pace of dying requires — and, perhaps most maddeningly, failing in precisely the same way as we did earlier in the year. That is, out of apparent, near-total indifference.
+=====Blood Clots Linked to AstraZeneca Vaccine Stem From Rare Antibody Reaction=====
+[https://www.nytimes.com/2021/04/09/health/vaccine-blood-clots-astra-zeneca.html?action=click&module=Top%20Stories&pgtype=Homepage NYT By Denise Grady April 9, 2021]
+ Scientific teams from Germany and Norway found that people who developed the clots after vaccination had produced antibodies that activated their platelets, a blood component involved in clotting. The new reports add extensive details to what the researchers have already stated publicly about the blood disorder.
+=====Excess mortality during the Coronavirus pandemic (COVID-19)=====
+[https://ourworldindata.org/excess-mortality-covid Our World Data]
+ The chart here shows excess mortality during the pandemic for all ages using the P-score.6 To see the P-scores for other countries click  Add country on the chart.
+=====Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host=====
+[https://www.nejm.org/doi/full/10.1056/NEJMc2031364 New England Journal of Medicine 12/03/20
+ Although most immunocompromised persons effectively clear SARS-CoV-2 infection, this case highlights the potential for persistent infection5 and accelerated viral evolution associated with an immunocompromised state.
+=====Extraordinary Patient Offers Surprising Clues To Origins Of Coronavirus Variants=====
+[https://www.npr.org/sections/goatsandsoda/2021/02/05/964447070/where-did-the-coronavirus-variants-come-from NPR 2/02/21 MICHAELEEN DOUCLEFF]
+ The sequences showed Li and his team that the virus was changing very quickly inside the man's body. The virus wasn't picking up just one or two mutations at a time. But rather, it acquired a whole cluster of more than 20 mutations. Scientists had never seen SARS-Cov-2 mutate so quickly during the whole pandemic.
+===== Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection =====
+[https://jamanetwork.com/journals/jamacardiology/fullarticle/2770645?guestAccessKey=ad3c4563-167f-452a-917f-7bfe15663b06&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091120 JAMA Network Saurabh Rajpal, MBBS, MD1; Matthew S. Tong, DO1; James Borchers, MD, MPH1; et alKarolina M. Zareba, MD1; Timothy P. Obarski, DO1; Orlando P. Simonetti, PhD1; Curt J. Daniels, MD1 9/11/20]
+ Of 26 competitive athletes, 4 (15%) had CMR findings suggestive of myocarditis and 8 additional athletes (30.8%) exhibited LGE without T2 elevation suggestive of prior myocardial injury. COVID-19–related myocardial injury in competitive athletes and sports participation remains unclear.
+====='Toxic Individualism': Pandemic Politics Driving Health Care Workers From Small Towns=====
+[https://www.npr.org/2020/12/28/950861977/toxic-individualism-pandemic-politics-driving-health-care-workers-from-small-tow NPR 12/29/20 Frank Morris]
+  Rural hospitals were in deep trouble before the pandemic. Morgan says 132 of them have closed since 2010. COVID-19 made matters worse. The surge of desperately sick and highly contagious patients stopped hospitals from doing the lucrative elective outpatient procedures that keep them in business. Their small staffs have been run ragged. And the pandemic has filled the air with vitriol against medical expertise.
+ More than a quarter of all the public health administrators in Kansas quit, retired or got fired this year, according to Vicki Collie-Akers, an associate professor of population health at the University of Kansas. Some of them got death threats. Some had to hire armed guards.
+===== Hunting for 'Disease X' =====
+[https://www.cnn.com/2020/12/22/africa/drc-forest-new-virus-intl/index.html Sam Kiley  Tue December 22, 2020]
+Humanity faces an unknown number of new and potentially fatal viruses emerging from Africa's tropical rainforests, according to Professor Jean-Jacques Muyembe Tamfum, who helped discover the Ebola virus in 1976 and has been on the frontline of the hunt for new pathogens ever since.
+"We are now in a world where new pathogens will come out," he told CNN. "And that's what constitutes a threat for humanity."
+As a young researcher, Muyembe took the first blood samples from the victims of a mysterious disease that caused hemorrhages and killed about 88% of patients and 80% of the staff who were working at the Yambuku Mission Hospital when the disease was first discovered.
+=====A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged=====
+[https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63 A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged] Elemental
+Thomas Smith Aug 31·2020 8 min read
+A closer look at the Bradykinin hypothesis
+ Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week.
+ According to the team’s findings, a Covid-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose, (The receptors, which the virus is known to target, are abundant there.) The virus then proceeds through the body, entering cells in other places where ACE2 is also present: the intestines, kidneys, and heart. This likely accounts for at least some of the disease’s cardiac and GI symptoms.
+=====The True Coronavirus Toll in the U.S. Has Already Surpassed 200,000=====
+<embed> https://www.nytimes.com/interactive/2020/08/12/us/covid-deaths-us.html?action=click&module=Top%20Stories&pgtype=Homepage </embed>
+NY Times By Denise LuAug. 13, 2020
+ Across the United States, at least 200,000 more people have died than usual since March, according to a New York Times analysis of estimates from the Centers for Disease Control and Prevention. This is about 60,000 higher than the number of deaths that have been directly linked to the coronavirus.
+=====Smallpox and other viruses plagued humans much earlier than suspected=====
+<embed> https://www.nature.com/articles/d41586-020-02083-0?utm_source=Nature%20Briefing&utm_campaign=a0e80cbbed-briefing-dy-20200724&utm_medium=email&utm_term=0_c9dfd39373-a0e80cbbed-42787455&fbclid=IwAR2saXk615K6gst45KlLNiavgGkaQrYa_kMrNYHCHXmsyAXq0331iZp_RYo </embed>Nature Laura Spinney 23 JULY 2020
+ The death date of smallpox is clear. After killing more than 300 million people in the twentieth century, it claimed its last victim in 1978; two years later, on 8 May 1980, the World Health Assembly declared that the variola virus, which causes smallpox, had been eradicated. But the origins of this devastating virus are obscure. Now, genetic evidence is starting to uncover when smallpox first started attacking people.
+ Humans as far back as AD 600 carried variola, an international research team reported this week1 after years of fishing for viral DNA in ancient human remains. The analysis also implies that the virus was circulating in humans even earlier: at least 1,700 years back, in the turbulent period around the fall of the Western Roman Empire, when many peoples were migrating across Eurasia.
+=====Inside the body, the coronavirus is even more sinister than scientists had realized=====
+<embed> https://www.latimes.com/science/story/2020-06-26/inside-the-body-the-coronavirus-is-even-more-sinister-than-scientists-had-realized?fbclid=IwAR0XPpIpcjzT8cBk9PR3clOp6r1hPE3SO3MBdGDX5R5S2wPGHZS1EFW-RSk </embed>
+ Researchers exploring the interaction between the coronavirus and its hosts have discovered that when the SARS-CoV-2 virus infects a human cell, it sets off a ghoulish transformation. Obeying instructions from the virus, the newly infected cell sprouts multi-pronged tentacles studded with viral particles.
+ These disfigured zombie cells appear to be using those streaming filaments, or filopodia, to reach still-healthy neighboring cells. The protuberances appear to bore into the cells’ bodies and inject their viral venom directly into those cells’ genetic command centers — thus creating another zombie.
+=====We Have No Idea If Covid Immune Responses Fall Off Rapidly in Cases Where There Is A Full Response!=====
+<embed> https://www.dailykos.com/stories/2020/7/13/1960485/-We-Have-No-Idea-If-Covid-Immune-Responses-Fall-Off-Rapidly-in-Cases-Where-There-Is-A-Full-Response?utm_campaign=spotlight </embed> DailyKos July 13 2020
+ We barely understand how the immune system works, actually, that isn’t completely accurate, we know parts of it.  We know that a full response involves numerous cell types.  Making antibody isn’t the end-all and be-all of the immune response.  As I wrote above, long-term immunity requires T and other types of cells.  We don’t even fully understand how long term anti-body responses work, completely.  What triggers are necessary to get anti-body production upon reexposure?  None of these studies are looking at the immune responses of the folks they are examining, they are looking at one aspect of a very complex system and drawing huge conclusions about the importance of the work.
+=====COVID-19 Antibody Response Drops in 3 Months According to Kings College London Report in Review =====
+<embed> https://www.dailykos.com/stories/2020/7/13/1960341/-COVID-19-Antibody-Response-Drops-in-3-Months-According-to-Kings-College-London-Report-in-Review?utm_campaign=trending </embed>
+ In the first longitudinal study of its kind, scientists analysed the immune response of more than 90 patients and healthcare workers at Guy’s and St Thomas’ NHS foundation trust and found levels of antibodies that can destroy the virus peaked about three weeks after the onset of symptoms then swiftly declined.
 =====I'm a physiotherapist. Seeing the impact of Covid on survivors will haunt me forever=====
@@ Line 7: / Line 92: @@
   I’ve never seen anything like coronavirus before. Recovering will be a Herculean task for patients, but we are here to help.
   But never have I seen the cracked-glass effect on lung CT scans like those of Covid-19 patients. I have stared at them wondering where the breath is coming from, worrying if they will be able to conjure up the respiratory effort to sit, stand, step, move, live. Those scans will skulk in the depths of my brain for the rest of my days.
-<embed> https://www.nature.com/articles/s41591-020-0965-6 </embed>
+=====Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections=====
+[https://www.nature.com/articles/s41591-020-0965-6 | Nature Published: 18 June 2020]
+ These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.
 <embed> https://www.dailykos.com/stories/2020/6/24/1955596/-Widely-cited-study-has-left-some-doubting-a-COVID-19-vaccine-is-possible-but-not-so-fast </embed>

Health Care-Illness: Difference between revisions

Latest revision as of 10:43, 13 March 2022

Contents

America's Vaccine Rollout Disaster

Blood Clots Linked to AstraZeneca Vaccine Stem From Rare Antibody Reaction

Excess mortality during the Coronavirus pandemic (COVID-19)

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

Extraordinary Patient Offers Surprising Clues To Origins Of Coronavirus Variants

Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection

'Toxic Individualism': Pandemic Politics Driving Health Care Workers From Small Towns

Hunting for 'Disease X'

A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged

The True Coronavirus Toll in the U.S. Has Already Surpassed 200,000

Smallpox and other viruses plagued humans much earlier than suspected

Inside the body, the coronavirus is even more sinister than scientists had realized

We Have No Idea If Covid Immune Responses Fall Off Rapidly in Cases Where There Is A Full Response!

COVID-19 Antibody Response Drops in 3 Months According to Kings College London Report in Review

I'm a physiotherapist. Seeing the impact of Covid on survivors will haunt me forever

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

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