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=====A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged===== | =====A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged===== | ||
[https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63 A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged] Elemental | |||
Thomas Smith Aug 31·2020 8 min read | Thomas Smith Aug 31·2020 8 min read | ||
A closer look at the Bradykinin hypothesis | |||
A closer look at the Bradykinin hypothesis | |||
Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week. | Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week. | ||
According to the team’s findings, a Covid-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose, (The receptors, which the virus is known to target, are abundant there.) The virus then proceeds through the body, entering cells in other places where ACE2 is also present: the intestines, kidneys, and heart. This likely accounts for at least some of the disease’s cardiac and GI symptoms. | According to the team’s findings, a Covid-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose, (The receptors, which the virus is known to target, are abundant there.) The virus then proceeds through the body, entering cells in other places where ACE2 is also present: the intestines, kidneys, and heart. This likely accounts for at least some of the disease’s cardiac and GI symptoms. | ||
Revision as of 13:38, 20 November 2020
A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged
A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged Elemental Thomas Smith Aug 31·2020 8 min read
A closer look at the Bradykinin hypothesis
Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week.
According to the team’s findings, a Covid-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose, (The receptors, which the virus is known to target, are abundant there.) The virus then proceeds through the body, entering cells in other places where ACE2 is also present: the intestines, kidneys, and heart. This likely accounts for at least some of the disease’s cardiac and GI symptoms.
<embed> https://www.nytimes.com/interactive/2020/08/12/us/covid-deaths-us.html?action=click&module=Top%20Stories&pgtype=Homepage </embed> NY Times By Denise LuAug. 13, 2020
Across the United States, at least 200,000 more people have died than usual since March, according to a New York Times analysis of estimates from the Centers for Disease Control and Prevention. This is about 60,000 higher than the number of deaths that have been directly linked to the coronavirus.
Smallpox and other viruses plagued humans much earlier than suspected
<embed> https://www.nature.com/articles/d41586-020-02083-0?utm_source=Nature%20Briefing&utm_campaign=a0e80cbbed-briefing-dy-20200724&utm_medium=email&utm_term=0_c9dfd39373-a0e80cbbed-42787455&fbclid=IwAR2saXk615K6gst45KlLNiavgGkaQrYa_kMrNYHCHXmsyAXq0331iZp_RYo </embed>Nature Laura Spinney 23 JULY 2020
The death date of smallpox is clear. After killing more than 300 million people in the twentieth century, it claimed its last victim in 1978; two years later, on 8 May 1980, the World Health Assembly declared that the variola virus, which causes smallpox, had been eradicated. But the origins of this devastating virus are obscure. Now, genetic evidence is starting to uncover when smallpox first started attacking people.
Humans as far back as AD 600 carried variola, an international research team reported this week1 after years of fishing for viral DNA in ancient human remains. The analysis also implies that the virus was circulating in humans even earlier: at least 1,700 years back, in the turbulent period around the fall of the Western Roman Empire, when many peoples were migrating across Eurasia.
Researchers exploring the interaction between the coronavirus and its hosts have discovered that when the SARS-CoV-2 virus infects a human cell, it sets off a ghoulish transformation. Obeying instructions from the virus, the newly infected cell sprouts multi-pronged tentacles studded with viral particles. These disfigured zombie cells appear to be using those streaming filaments, or filopodia, to reach still-healthy neighboring cells. The protuberances appear to bore into the cells’ bodies and inject their viral venom directly into those cells’ genetic command centers — thus creating another zombie.
We Have No Idea If Covid Immune Responses Fall Off Rapidly in Cases Where There Is A Full Response!
<embed> https://www.dailykos.com/stories/2020/7/13/1960485/-We-Have-No-Idea-If-Covid-Immune-Responses-Fall-Off-Rapidly-in-Cases-Where-There-Is-A-Full-Response?utm_campaign=spotlight </embed> DailyKos July 13 2020
We barely understand how the immune system works, actually, that isn’t completely accurate, we know parts of it. We know that a full response involves numerous cell types. Making antibody isn’t the end-all and be-all of the immune response. As I wrote above, long-term immunity requires T and other types of cells. We don’t even fully understand how long term anti-body responses work, completely. What triggers are necessary to get anti-body production upon reexposure? None of these studies are looking at the immune responses of the folks they are examining, they are looking at one aspect of a very complex system and drawing huge conclusions about the importance of the work.
COVID-19 Antibody Response Drops in 3 Months According to Kings College London Report in Review
In the first longitudinal study of its kind, scientists analysed the immune response of more than 90 patients and healthcare workers at Guy’s and St Thomas’ NHS foundation trust and found levels of antibodies that can destroy the virus peaked about three weeks after the onset of symptoms then swiftly declined.
I'm a physiotherapist. Seeing the impact of Covid on survivors will haunt me forever
<embed> https://www.theguardian.com/society/2020/jun/25/physiotherapist-seeing-impact-covid-survivors-haunt-forever </embed>
I’ve never seen anything like coronavirus before. Recovering will be a Herculean task for patients, but we are here to help. But never have I seen the cracked-glass effect on lung CT scans like those of Covid-19 patients. I have stared at them wondering where the breath is coming from, worrying if they will be able to conjure up the respiratory effort to sit, stand, step, move, live. Those scans will skulk in the depths of my brain for the rest of my days.
Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
| Nature Published: 18 June 2020
These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.
<embed> https://www.dailykos.com/stories/2020/6/24/1955596/-Widely-cited-study-has-left-some-doubting-a-COVID-19-vaccine-is-possible-but-not-so-fast </embed>
