New polymer-coated vitamins and minerals
Science Mag 11/13/19
Frustrated by such failures, health policy experts at the Bill & Melinda Gates Foundation in Seattle, Washington, sought the help of Jaklenec and her supervisor, Robert Langer, an MIT chemical engineer who has pioneered numerous dissolvable coatings for protecting and delivering fragile medicines.
Jaklenec, Langer, and their colleagues initially considered more than 50 different polymer coatings that were stable in boiling water but would dissolve in the stomach’s acidic environment. After narrowing the list to 10 candidates and studying each closely, they settled on a polymer known as BMC. A protective coating in dietary supplements, BMC is already approved by the Food and Drug Administration (and therefore considered safe). The MIT team coated 11 micronutrient powders in BMC, including iron, zinc, folate, vitamin A, and vitamin D. They also coated microparticles containing up to four different vitamins and minerals. Lab testing showed that all stood up well to heat, ultraviolet light, and even 2 hours straight of being cooked in boiling water. The particles also readily dissolved in a low pH solution meant to mimic stomach acid.
