HIV AIDS: Difference between revisions

Line 89:

[https://www.sciencedirect.com/science/article/pii/S1931312813002187 by Lucie Etienne 17/7/13 ScienceDirect]

HIV-1 resulted from cross-species transmission of SIVcpz, a simian immunodeficiency virus that naturally infects chimpanzees. SIVcpz, in turn, is a recombinant between two SIV lineages from Old World monkeys. Lentiviral interspecies transmissions are partly driven by the evolution and capacity of viral accessory genes, such as vpx, vpr, and vif, to antagonize host antiviral factors, such as SAMHD1 and the APOBEC3 proteins. We show that vpx, which in other lentiviruses antagonizes SAMHD1, was deleted during the creation of SIVcpz.

=====The origin and diversity of the HIV-1 pandemic=====

[https://www.sciencedirect.com/science/article/abs/pii/S1471491411002103 by Joris Hemelaar 3/12 ScienceDirect]

This review examines the enormous progress that has been made in the past decade in understanding the origin of HIV, HIV genetic variability, and the impact of global HIV diversity on the pandemic. Multiple zoonotic transmissions of simian immunodeficiency virus (SIV) have resulted in different HIV lineages in humans. In addition, the high mutation and recombination rates during viral replication result in a great genetic variability of HIV within individuals, as well as within populations, upon which evolutionary selection pressures act.

HIV AIDS: Difference between revisions

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@@ Line 89: / Line 89: @@
 [https://www.sciencedirect.com/science/article/pii/S1931312813002187 by Lucie Etienne  17/7/13 ScienceDirect]
   HIV-1 resulted from cross-species transmission of SIVcpz, a simian immunodeficiency virus that naturally infects chimpanzees. SIVcpz, in turn, is a recombinant between two SIV lineages from Old World monkeys. Lentiviral interspecies transmissions are partly driven by the evolution and capacity of viral accessory genes, such as vpx, vpr, and vif, to antagonize host antiviral factors, such as SAMHD1 and the APOBEC3 proteins. We show that vpx, which in other lentiviruses antagonizes SAMHD1, was deleted during the creation of SIVcpz.
+=====The origin and diversity of the HIV-1 pandemic=====
+[https://www.sciencedirect.com/science/article/abs/pii/S1471491411002103 by Joris Hemelaar 3/12 ScienceDirect]
+ This review examines the enormous progress that has been made in the past decade in understanding the origin of HIV, HIV genetic variability, and the impact of global HIV diversity on the pandemic. Multiple zoonotic transmissions of simian immunodeficiency virus (SIV) have resulted in different HIV lineages in humans. In addition, the high mutation and recombination rates during viral replication result in a great genetic variability of HIV within individuals, as well as within populations, upon which evolutionary selection pressures act.