HIV AIDS: Difference between revisions
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[https://www.pnas.org/doi/10.1073/pnas.1502022112 by Mirela D’arc 2/3/15 PNAS] | [https://www.pnas.org/doi/10.1073/pnas.1502022112 by Mirela D’arc 2/3/15 PNAS] | ||
Understanding emerging disease origins is important to gauge future human infection risks. This is particularly true for the various forms of the AIDS virus, HIV-1, which were transmitted to humans on four independent occasions. Previous studies identified chimpanzees in southern Cameroon as the source of the pandemic M group, as well as the geographically more restricted N group. | Understanding emerging disease origins is important to gauge future human infection risks. This is particularly true for the various forms of the AIDS virus, HIV-1, which were transmitted to humans on four independent occasions. Previous studies identified chimpanzees in southern Cameroon as the source of the pandemic M group, as well as the geographically more restricted N group. | ||
=====Endogenous Origins of HIV-1 G-to-A Hypermutation and Restriction in the Nonpermissive T Cell Line CEM2n===== | |||
[https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002800 by Eric W. Refsland 12/7/12 PLOS] | |||
The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral genetic diversity and the associated problems of drug resistance and immune escape. | |||
