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|'''Three independent studies say that blood platelet factor PF4 prevents and reverses cognitive decline'''
|'''Three independent studies say that blood platelet factor PF4 prevents and reverses cognitive decline'''
[[File:Blood platlets.jpg|thumb|center|[https://www.dailykos.com/stories/2023/8/18/2187800/-Three-independent-studies-say-that-blood-platelet-factor-PF4-prevents-and-reverses-cognitive-decline by skralyx 8/18/2023 DailyKos]]]
[[File:Blood platlets.jpg|thumb|center|[https://www.dailykos.com/stories/2023/8/18/2187800/-Three-independent-studies-say-that-blood-platelet-factor-PF4-prevents-and-reverses-cognitive-decline by skralyx 8/18/2023 DailyKos]]]
  The three studies all landed on PF4 in different ways.  Villeda knew that young blood transfusions restore cognitive function, so he kept testing different blood fractions until he narrowed it down to PF4.  Dubal has long been interested in the anti-aging properties of a protein called klotho, and her paper shows that klotho induces PF4 production, and that’s what led her to test PF4 directly.  Then Walker was trying to get at why exercise indisputably enhances cognition, and she found that exercise activates platelets, which then secrete — you guessed it — PF4.  That’s a remarkable convergence that makes me think this is rock solid.
  The three studies all landed on PF4 in different ways.  Villeda knew that young blood transfusions restore cognitive function, so he kept testing different blood fractions until he narrowed it down to PF4.  Dubal has long been interested in the anti-aging properties of a protein called klotho, and her paper shows that klotho induces PF4 production, and that’s what led her to test PF4 directly.  Then Walker was trying to get at why exercise indisputably enhances cognition, and she found that exercise activates platelets, which then secrete — you guessed it — PF4.  That’s a remarkable convergence that makes me think this is rock solid.[http://chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://homelessness.ucsf.edu/sites/default/files/2023-06/CASPEH_Report_62023.pdf California Homeless Study PDF]