Malaria: Difference between revisions

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[https://www.npr.org/2023/09/20/1200528621/bangladesh-has-been-effective-at-fighting-malaria-can-it-eliminate-the-disease by Ari Daniel 20/9/23 npr]

Malaria has plagued humanity for millennia. According to the World Health Organization, it kills more than 600,000 people a year, mostly in Africa. And that's despite enormous efforts to develop treatments and control the mosquitoes that carry the disease. There are some bright spots, though. Reporter Ari Daniel takes us to Bangladesh, a country that's slashed its malaria numbers drastically, though the parasite isn't going down without a fight.

=====An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein=====

[https://www.nature.com/articles/s41541-020-00274-4 by Lucie Jelínková 21/1/21 npj]

A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy of a vaccine targeting a recently described epitope on the major surface antigen on Plasmodium falciparum sporozoites, circumsporozoite protein (CSP). Using a virus-like particle (VLP)-based vaccine platform technology, we developed a vaccine that targets the junctional region between the N-terminal and central repeat regions of CSP.

Malaria: Difference between revisions

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@@ Line 139: / Line 139: @@
 [https://www.npr.org/2023/09/20/1200528621/bangladesh-has-been-effective-at-fighting-malaria-can-it-eliminate-the-disease by Ari Daniel 20/9/23 npr]
   Malaria has plagued humanity for millennia. According to the World Health Organization, it kills more than 600,000 people a year, mostly in Africa. And that's despite enormous efforts to develop treatments and control the mosquitoes that carry the disease. There are some bright spots, though. Reporter Ari Daniel takes us to Bangladesh, a country that's slashed its malaria numbers drastically, though the parasite isn't going down without a fight.
+=====An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein=====
+[https://www.nature.com/articles/s41541-020-00274-4 by Lucie Jelínková 21/1/21 npj]
+ A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy of a vaccine targeting a recently described epitope on the major surface antigen on Plasmodium falciparum sporozoites, circumsporozoite protein (CSP). Using a virus-like particle (VLP)-based vaccine platform technology, we developed a vaccine that targets the junctional region between the N-terminal and central repeat regions of CSP.