HIV AIDS: Difference between revisions
From WikiDemocracy
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 101: | Line 101: | ||
[https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002800 by Eric W. Refsland 12/7/12 PLOS] | [https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002800 by Eric W. Refsland 12/7/12 PLOS] | ||
The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral genetic diversity and the associated problems of drug resistance and immune escape. | The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral genetic diversity and the associated problems of drug resistance and immune escape. | ||
=====HIV Originated With Monkeys, Not Chimps, Study Finds===== | |||
[https://www.nationalgeographic.com/science/article/news-hiv-aids-monkeys-chimps-origin by Stefan Lovgren 3/5/21 NATIONAL GEOGRAPHIC] | |||
Researchers believe the chimpanzee virus is a hybrid of the SIVs naturally infecting two different monkeys, the red-capped mangabey (Cercocebus torquatus) and the greater spot-nosed monkey (Cercopithecus nictitans). Chimps eat monkeys, which is likely how they acquired the monkey viruses. The hybrid virus then spread through the chimpanzee species, and was later transmitted to humans to become HIV-1. | |||
