HIV AIDS: Difference between revisions

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[https://www.nature.com/articles/428820a by Michael Worobey 22/4/04 nature]

Despite strong evidence to the contrary1,2,3,4,5, speculation continues that the AIDS virus, human immunodeficiency virus type 1 (HIV-1), may have crossed into humans as a result of contamination of the oral polio vaccine (OPV)6,7,8. This ‘OPV/AIDS theory’ claims that chimpanzees from the vicinity of Stanleyville — now Kisangani in the Democratic Republic of Congo — were the source of a simian immunodeficiency virus (SIVcpz) that was transmitted to humans when chimpanzee tissues were allegedly used in the preparation of OPV6,7.

=====Origin and Epidemiological History of HIV-1 CRF14_BG=====

[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024130 by Inês Bártolo Inês 28/9/11 PLOS One]

C2V3C3 env gene sequences were obtained from 62 samples collected in 1993–1998 from Portuguese HIV-1 patients. Full-length genomic sequences were obtained from three patients. Viral subtypes, diversity, divergence rate and positive selection were investigated by phylogenetic analysis. The molecular structure of the genomes was determined by bootscanning. A relaxed molecular clock model was used to date the origin of CRF14_BG. Geno2pheno was used to predict viral tropism. Subtype B was the most prevalent subtype (45 sequences; 73%) followed by CRF14_BG (8; 13%), G (4; 6%), F1 (2; 3%), C (2; 3%) and CRF02_AG (1; 2%).

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@@ Line 109: / Line 109: @@
 [https://www.nature.com/articles/428820a by Michael Worobey 22/4/04 nature]
   Despite strong evidence to the contrary1,2,3,4,5, speculation continues that the AIDS virus, human immunodeficiency virus type 1 (HIV-1), may have crossed into humans as a result of contamination of the oral polio vaccine (OPV)6,7,8. This ‘OPV/AIDS theory’ claims that chimpanzees from the vicinity of Stanleyville — now Kisangani in the Democratic Republic of Congo — were the source of a simian immunodeficiency virus (SIVcpz) that was transmitted to humans when chimpanzee tissues were allegedly used in the preparation of OPV6,7.
+=====Origin and Epidemiological History of HIV-1 CRF14_BG=====
+[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024130 by Inês Bártolo Inês 28/9/11 PLOS One]
+ C2V3C3 env gene sequences were obtained from 62 samples collected in 1993–1998 from Portuguese HIV-1 patients. Full-length genomic sequences were obtained from three patients. Viral subtypes, diversity, divergence rate and positive selection were investigated by phylogenetic analysis. The molecular structure of the genomes was determined by bootscanning. A relaxed molecular clock model was used to date the origin of CRF14_BG. Geno2pheno was used to predict viral tropism. Subtype B was the most prevalent subtype (45 sequences; 73%) followed by CRF14_BG (8; 13%), G (4; 6%), F1 (2; 3%), C (2; 3%) and CRF02_AG (1; 2%).