Vitamin D

Impact of vitamin D status on statin-induced myopathy

[https://www.sciencedirect.com/science/article/pii/S2214623716300503 by Krista D. Riche Pharm.D. a b, Justin Arnall Pharm.D.,Kristin Rieser Pharm. Honey E. East M.D. d Daniel M. Riche Pharm.D., FCCP, BCPS, CDE, ASH-CHC, CLS 12/2016 Journal of Clinical & Translational Endocrinology]

There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non-adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Since there is no consensus on a treatment course of action for statin-induced myopathy, investigation into potential confounders to elucidate the dynamics of statin-induced myopathy is warranted.

A dose of vitamin D history

by nature structural & molecular biology 2/22

Our bodies are capable of producing vitamin D — we are not entirely dependent on obtaining it from food, as is the case with other 'true' vitamins. In fact, we can produce enough vitamin D to maintain essential processes when our skin is adequately exposed to the ultraviolet rays in sunlight.

Vitamin D deficiency 2.0: an update on the current status worldwide

by Karin Amrein 20/1/20 nature

Vitamin D testing and the use of vitamin D supplements have increased substantially in recent years. Currently, the role of vitamin D supplementation, and the optimal vitamin D dose and status, is a subject of debate, because large interventional studies have been unable to show a clear benefit (in mostly vitamin D replete populations).

Official recommendations for vitamin D through the life stages in developed countries

by Samantha M. Kimball 20/8/20 EJCN

Inadequate vitamin D nutritional status is prevalent worldwide and has been associated with autoimmune disorders, heart disease, deadly cancers, insulin resistance, inflammation, neurological disorders, adverse outcomes in pregnancy, and increased risk for mortality. Expert recommendations for vitamin D intake differ between governmental agencies and practice guidelines from medical societies due to differences in the definition of vitamin D deficiency, insufficiency and sufficiency based on serum 25-hydroxyvitamin D [25(OH)D] concentrations.

Making vitamin D detection much more accessible

by nature research custom media nature portfolio

Despite the importance of vitamin D for overall health, it is estimated that about one billion people worldwide have a deficiency, usually defined as having serum levels of 25-hydroxyvitamin D3 (25(OH)D3) — the major circulating form of vitamin D — below 20 nanograms per millilitre (ng/ml).

Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial

by Deirdre K. Tobias 8/4/25 nature communications

Observational and experimental evidence suggests that vitamin D plays a role in type 2 diabetes (T2D). However, prior randomized supplementation trials are limited to high-risk patients with prediabetes. Here we aim to evaluate whether vitamin D supplementation reduces risk of T2D in a general population of older US adults.

Vitamin D metabolites and the gut microbiome in older men

by Robert L. Thomas 26/11/20 nature communications

The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA gene sequencing data.