Vitamin D

Impact of vitamin D status on statin-induced myopathy

[https://www.sciencedirect.com/science/article/pii/S2214623716300503 by Krista D. Riche Pharm.D. a b, Justin Arnall Pharm.D.,Kristin Rieser Pharm. Honey E. East M.D. d Daniel M. Riche Pharm.D., FCCP, BCPS, CDE, ASH-CHC, CLS 12/2016 Journal of Clinical & Translational Endocrinology]

There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non-adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Since there is no consensus on a treatment course of action for statin-induced myopathy, investigation into potential confounders to elucidate the dynamics of statin-induced myopathy is warranted.

A dose of vitamin D history

by nature structural & molecular biology 2/22

Our bodies are capable of producing vitamin D — we are not entirely dependent on obtaining it from food, as is the case with other 'true' vitamins. In fact, we can produce enough vitamin D to maintain essential processes when our skin is adequately exposed to the ultraviolet rays in sunlight.

Vitamin D deficiency 2.0: an update on the current status worldwide

by Karin Amrein 20/1/20 nature

Vitamin D testing and the use of vitamin D supplements have increased substantially in recent years. Currently, the role of vitamin D supplementation, and the optimal vitamin D dose and status, is a subject of debate, because large interventional studies have been unable to show a clear benefit (in mostly vitamin D replete populations).

Official recommendations for vitamin D through the life stages in developed countries

by Samantha M. Kimball 20/8/20 EJCN

Inadequate vitamin D nutritional status is prevalent worldwide and has been associated with autoimmune disorders, heart disease, deadly cancers, insulin resistance, inflammation, neurological disorders, adverse outcomes in pregnancy, and increased risk for mortality. Expert recommendations for vitamin D intake differ between governmental agencies and practice guidelines from medical societies due to differences in the definition of vitamin D deficiency, insufficiency and sufficiency based on serum 25-hydroxyvitamin D [25(OH)D] concentrations.

Making vitamin D detection much more accessible

by nature research custom media nature portfolio

Despite the importance of vitamin D for overall health, it is estimated that about one billion people worldwide have a deficiency, usually defined as having serum levels of 25-hydroxyvitamin D3 (25(OH)D3) — the major circulating form of vitamin D — below 20 nanograms per millilitre (ng/ml).

Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial

by Deirdre K. Tobias 8/4/25 nature communications

Observational and experimental evidence suggests that vitamin D plays a role in type 2 diabetes (T2D). However, prior randomized supplementation trials are limited to high-risk patients with prediabetes. Here we aim to evaluate whether vitamin D supplementation reduces risk of T2D in a general population of older US adults.

Vitamin D metabolites and the gut microbiome in older men

by Robert L. Thomas 26/11/20 nature communications

The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA gene sequencing data.

New aspects of vitamin D metabolism and action — addressing the skin as source and target

by Daniel Bikle 6/2/20 nature reviews

Vitamin D has a key role in stimulating calcium absorption from the gut and promoting skeletal health, as well as many other important physiological functions. Vitamin D is produced in the skin. It is subsequently metabolized to its hormonally active form, 1,25-dihydroxyvitamin D (1,25(OH)2D), by the 1-hydroxylase and catabolized by the 24-hydroxylase. In this Review, we pay special attention to the effect of mutations in these enzymes and their clinical manifestations.

Vitamin D testing: advantages and limits of the current assays

by Barbara Altieri 6/1/20 EJCN

Vitamin D deficiency and insufficiency has become a pandemic health problem with a consequent increase of requests for determining circulating levels of 25-hydroxyvitamin D [25(OH)D]. However, the analytical performance of these immunoassays, including radioimmunoassay and ELISA, is highly variable, and even mass spectrometric methods, which nowadays serves as the gold standard for the quantitatively determination of 25(OH)D, do not necessarily produce comparable results, creating limitations for the definition of normal vitamin D status ranges.

The Vitamin D Connection to Pediatric Infections and Immune Function

by Valencia P Walker 5/09 Pediatric RESEARCH

Over the past 20 y, a resurgence in vitamin D deficiency and nutritional rickets has been reported throughout the world, including the United States. Inadequate serum vitamin D concentrations have also been associated with complications from other health problems, including tuberculosis, cancer (prostate, breast, and colon), multiple sclerosis, and diabetes.

Exploring vitamin D metabolism and function in cancer

by Sang-Min Jeon 16/4/18 EMM

Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid hormone that regulates a broad spectrum of physiological processes. In addition to its classical roles in bone metabolism, epidemiological, preclinical, and cellular research during the last decades, it revealed that vitamin D may play a key role in the prevention and treatment of many extra-skeletal diseases such as cancer.

Vitamin D for COVID-19: where are we now?

by Adrian R. Martineau 22/7/22 nature reviews immunology

Early in the COVID-19 pandemic, a lack of vaccines and therapies prompted interest in a potential role for vitamin D in reducing risk or severity of disease. This was based on the recognized effects of vitamin D on host responses to other respiratory viruses, and evidence from randomized controlled trials (RCTs) showing the efficacy of vitamin D supplementation for the prevention of other acute respiratory infections. Since then, effective drugs and vaccines have been developed for COVID-19, with major effects on mortality.

The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals

by Parul Singh 10/12/20 scientific reports

Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied in patients with chronic diseases, its effects on the microbiota of otherwise healthy individuals is unclear.

Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish

by Megan M. Knuth 29/9/20 scientific reports

Emerging evidence demonstrates the importance of sufficient vitamin D (1α, 25-dihydroxyvitamin D3) levels during early life stage development with deficiencies associated with long-term effects into adulthood.

Effect of vitamin D on cognitive decline: results from two ancillary studies of the VITAL randomized trial

by Jae H. Kang 1/12/21 scientific reports

Low vitamin D levels have been associated with cognitive decline; however, few randomized trials have been conducted. In a trial, we evaluated vitamin D3 supplementation on cognitive decline.

Vitamin D supplementation: cholecalciferol, calcifediol, and calcitriol

by Reinhold Vieth 23/7/20 EJCN

The specific compound that is meant for use in the context of vitamin D supplementation is often ambiguous. The term “supplementation” has been used in the context of cholecalciferol, ergocalciferol, calcidiol, and calcitriol. In nature, by far the major form of vitamin D that nurtures the body is cholecalciferol.

Vitamin D status and associations with substance use patterns among people with severe substance use disorders in Western Norway

by Mitra Bemanian 11/8/22 scientific reports

Chronic and harmful substance use is associated with a cluster of harms to health, including micronutrient deficiencies. Maintaining adequate levels of vitamin D is important for musculoskeletal and other aspects of health.

Variability in response to vitamin D supplementation according to vitamin D metabolism related gene polymorphisms in healthy adults

by Mariem Ammar 27/9/22 EJCN

The aim of this study was to determine the influence of polymorphisms in some key gene actors of the vitamin D (vitD) metabolic pathway on supplementation efficacy.

Vitamin D Deficiency and Associated Risk Factors in Women from Riyadh, Saudi Arabia

by Nora A. AlFaris 30/12/19 scientific reports

Vitamin D deficiency is an epidemic public health problem worldwide. It is common in the Middle East and is more severe in women. This cross-sectional study was conducted to assess vitamin D deficiency and associated risk factors in women living in Riyadh, Saudi Arabia. Serum 25-hydroxyvitamin D (25(OH)D) was measured in 166 women aged 30–65 years.

The role of vitamin D in reducing cancer risk and progression

by David Feldman 4/4/14 nature reviews

Vitamin D3 is the precursor to the potent steroid hormone calcitriol (1,25 dihydroxyvitamin D3 (1,25(OH)2D3)) that regulates the expression of many genes in most tissues of the body.

New insights into the vitamin D requirements during pregnancy

by Bruce W Hollis 29/8/17 Bone Research

Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2–3 fold increase in the active hormone 1,25(OH)2D concentrations during the early weeks of pregnancy despite minimal increased calcium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodulatory role in preventing fetal rejection by the mother.

Comparative analysis of nutritional guidelines for vitamin D

by Roger Bouillon 7/4/17 nature reviews

Vitamin D is essential for calcium and bone homeostasis. Humans are largely dependent on UVB-radiation-induced photosynthesis of vitamin D, as few foods contain vitamin D.

A Quantitative Point-of-Need Assay for the Assessment of Vitamin D3 Deficiency

by S. Vemulapati 26/10/17 scientific reports

Vitamin D is necessary for the healthy growth and development of bone and muscle. Vitamin D deficiency, which is present in 42% of the US population, is often undiagnosed as symptoms may not manifest for several years and long-term deficiency has been linked to osteoporosis, diabetes and cancer.

Nutrition: The vitamin D complex

by Thea Singer 26/9/12 nature

My sister, Candice Singer, was a smoking fiend. Hooked since age 12, she was up to two packs a day by the time she started university, eventually rolling her own cigarettes to save money. In 2010, at age 50, she was diagnosed with chronic obstructive pulmonary disease (COPD) and needed to wear an oxygen mask at night to regulate her breathing while she slept.

Vitamin D status and arterial hypertension: a systematic review

by Stefan Pilz 18/10/09 nature reviews

Vitamin D deficiency is common and is primarily caused by a lack of ultraviolet-B (UVB) radiation from reduced sun exposure, and the consequent limiting of vitamin D production in the skin.

Mechanisms of Disease: vitamin D and inflammatory bowel disease

by Wee-Chian Lim 1/7/05 nature reviews

Until recently, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)—the active form of vitamin D—was thought to function primarily as a regulator of calcium and phosphate metabolism. More diverse functionality was indicated by the discovery of the vitamin D receptor in tissues that are not involved in calcium and phosphate homeostasis. Detection of the vitamin D receptor in monocytes and activated T cells has sparked interest in the immunomodulatory properties of vitamin D.