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The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies
Mushrooms have been used for various health conditions for many years by traditional medicines practiced in different regions of the world although the exact effects of mushroom extracts on the immune system are not fully understood. AHCC® is a standardized extract of cultured shiitake or Lentinula edodes mycelia (ECLM) which contains a mixture of nutrients including oligosaccharides, amino acids, and minerals obtained through liquid culture. AHCC® is reported to modulate the numbers and functions of immune cells including natural killer (NK) and T cells which play important roles in host defense, suggesting the possible implication of its supplementation in defending the host against infections and malignancies via modulating the immune system. Here, we review in vivo and in vitro effects of AHCC® on NK and T cells of humans and animals in health and disease, providing a platform for the better understanding of immune-mediated mechanisms and clinical implications of AHCC®.
AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections
by Judith A. Smith 21/6/22 frontiers
Objective: To determine the efficacy, safety, and durability of the use of AHCC supplementation for 6 months to support the host immune system to clear high-risk human papillomavirus (HPV) infections. The AHCC supplement is a proprietary, standardized extract of cultured lentinula edodes mycelia (AHCC®, Amino Up, Ltd., Sapporo, Japan) that has been shown to have unique immune modulatory benefits.
Lentinula edodes extract increases goblet cell number and Muc2 expression in an intestinal inflammatory model of Trichinella spiralis infection
by Beatriz López-Cauce 6/22 ScienceDirect
AHCC® is a standardized extract of cultured mushroom (Lentinula edodes) mycelia with a wide variety of therapeutic effects including anti-inflammatory, antitumor and antiviral effects. Trichinellosis, a food-borne parasitic zoonosis is caused by the nematode Trichinella spp. Infection with Trichinella is characterized by the induction of a Th1-type response at the beginning of the intestinal phase, followed by a dominant Th2-type response which is essential for parasite expulsion.
by Ritz Barry 11/06 ScienceDirect
The emergence of H5N1 avian influenza and the threat of new or adapted viruses in bioterrorism have created an urgent interest in identifying agents to enhance the immune response to primary virus infection. Active hexose correlated compound (AHCC) is a natural mushroom extract reported to increase natural killer (NK) cell activity, survival, and bacterial clearance in young mice. However, the effects of AHCC on the response to viral infections have not been studied. In this study, young C57BL/6 mice were supplemented with 1 g AHCC/(kg body weight · d) for 1 wk prior to and throughout infection with influenza A (H1N1, PR8).
by Reiki Ishizuka 7/12 ScienceDirect
Active hexose correlated compound (AHCC) and genistein concentrated polysaccharide (GCP) were administered to patients diagnosed with stage IV non-small cell lung cancer (NSCLC) with distant metastasis (M1). AHCC and GCP were consumed orally by concurrent or sequential use. Long-term follow-up study was conducted from January 1996 to January 2012 using the individualized evidence-based medicine (EBM) approach. Forty-two cases of NSCLC were enrolled in this study.
by Aya Hirose 15/7/07 ScienceDirect
Cisplatin (cis-diaminedichloroplatinum (II) or CDDP) (a widely used platinum-containing anticancer drug) is nephrotoxic and has a low percentage of tolerance in patients during chemotherapy. The active hexose correlated compound (AHCC) is an extract of Basidiomycotina marketed as a supplement for cancer patients due to its nutrients and fibre content and its ability to strengthen and optimize the capacity of the immune system.
by H. Fujii 3/11 ScienceDirect
Active Hexose Correlated Compound (AHCC), a mushroom extract rich in α-1,4 linked glucans, is associated with immunostimulatory effects. AHCC is used in Japan as a dietary supplement to boost immune function and it also is purported to improve the symptoms of cancer and liver disease patients. A series of toxicological studies were conducted on a freeze dried preparation of AHCC (AHCC-FD) to further develop the body of evidence supporting the safety of this ingredient. AHCC-FD was not mutagenic to Salmonella typhimurium and did not exhibit clastogenicity in a mouse micronucleus assay.
by Abdelali Daddaoua 15/2/13 ScienceDirect
Active Hexose Correlated Compound (AHCC) is an immunostimulatory nutritional supplement. AHCC effects and mechanism of action on intestinal epithelial cells or monocytes are poorly described. AHCC was added to the culture medium of intestinal epithelial cells (IEC18 and HT29 cells) and monocytes (THP-1 cells) and assessed the secretion of proinflammatory cytokines by ELISA. Inhibitors of NFκB and MAPKs were used to study signal transduction pathways while TLR4 and MyD88 were silenced in IEC18 cells using shRNA.
by Rosa Mistica Ignacio 12/15 ScienceDirect
While Active Hexose Correlated Compound (AHCC) and CpG oligodeoxynucleotide (ODN) are separately known to modulate oxidative stress and immune responses in cancer patients, the combined effect of these two compounds is unknown. To clarify this, we investigated whether AHCC plus KSK-CpG ODN would be therapeutic in B16 melanoma mouse model, if so, and how in reduction–oxidation (redox) balance and cytokines network. We found that treatment groups (AHCC only, KSK-CpG ODN only and AHCC/KSK-CpG ODN) markedly reduced (p < 0.001) tumor size when compared to the positive control (PC) group.
by Marie-Francoise Doursout Ph.D. 10/16 ScienceDirect
We hypothesized that AHCC; (Amino UP Chemical Co., Ltd., Sapporo, Japan), a mushroom mycelium extract obtained from liquid culture of Lentinula edodes, restores immune function in LPS-induced inflammation in the gut, especially when the nitric oxide signaling pathway is impaired. This is the first inter-disciplinary proposal to identify molecular mechanisms involved in LPS-induced immune dysfunction in the gut in conscious animals treated or non-treated with AHCC, a promoter of immune support. Specifically, we have tested the effects of AHCC on LPS-induced deleterious effects on blood pressure and gut injury in conscious rats.
AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation
by Loretta Olamigoke 15/12/15 WILEY
Active Hexose Correlated Compound (AHCC) is a fermented mushroom extract and immune supplement that has been used to treat a wide range of health conditions. It helps in augmentation of the natural immune response and affects immune cell activation and outcomes.
by Shuhui Wang 3/3/09 ScienceDirect
West Nile virus (WNV) poses a serious threat to public health, especially to the elderly and the immuno-compromised. Neither vaccines nor treatments are available for humans. Active hexose correlated compound (AHCC) is an extract of Lentinula edodes of the Basidiomycete family of fungi rich in α-glucans. In this study, we evaluated the effect of AHCC on host susceptibility in the murine model of WNV infection.
by Hernan Aviles M.D., Ph.D. 4/08 ScienceDirect
Infection is a serious, costly, and common complication of surgery and constitutes the principal cause of late death in patients undergoing surgery. The objective of this study was to clarify the mechanisms by which active hexose correlated compound (AHCC) increases survival in a murine model of intramuscular infection.
Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC
by Mehran Haidari 18/12/13 ScienceDirect
The effect of antioxidants on treatment of cancer is still controversial. Previously, we demonstrated that interaction of breast cancer cells with endothelial cells leads to tyrosine phosphorylation of VE-cadherin and disruption of endothelial adherens junction (EAJ). The molecular mechanism underlying the anti-metastatic effects of mushroom-derived active hexode correlated compound (AHCC) remains elusive.
by Abdelali Daddaoua 15/2/13 ScienceDirect
Active Hexose Correlated Compound (AHCC) is an immunostimulatory nutritional supplement. AHCC effects and mechanism of action on intestinal epithelial cells or monocytes are poorly described. AHCC was added to the culture medium of intestinal epithelial cells (IEC18 and HT29 cells) and monocytes (THP-1 cells) and assessed the secretion of proinflammatory cytokines by ELISA. Inhibitors of NFκB and MAPKs were used to study signal transduction pathways while TLR4 and MyD88 were silenced in IEC18 cells using shRNA.
by Won-Woo Lee 2/12 ScienceDirect
The differentiation of T helper (Th) cells is critically dependent on cytokine milieu. The innate immune monocytes produce IL-1β which can affect the development of Th17 and Th1 cells that predominantly produce IL-17 and IFN-γ, respectively. Oligosaccharides from microorganisms, crops and mushrooms can stimulate innate immune cells.
Shiitake-derived functional food shows suppression of liver fibrosis progression
by Osaka Metropolitan University 20/12/24 ScienceDaily
Chronic liver damage can lead to hepatitis, which causes fibrosis of the liver. This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during hepatitis, often resulting in liver cancer or cirrhosis, both of which can be fatal. As there are no effective drugs to treat cirrhosis, suppressing the activation of the stellate cells is considered as a way of controlling the progression of liver fibrosis.
Mushroom extract, AHCC, helpful in treating HPV
by University of Texas Health Science Center at Houston 28/10/14 ScienceDaily
A Japanese mushroom extract appears to be effective for the eradication of human papillomavirus (HPV), according to a pilot clinical trial at The University of Texas Health Science Center at Houston (UTHealth) Medical School.
Natural and synthetic drugs and formulations for intravaginal HPV clearance
by Nizar A. Khamjan 9/23 ScienceDirect
Several anti-HPV/HPV clearance compounds and formulations for high-grade lesions are undergoing clinical trials. However, the majority of compounds are still in the early stages of development and require additional research to become viable HPV clearance candidates. Synthetic drugs may be more promising because they may have a more targeted effect; however, they may also have significant adverse effects. On the other hand, natural medications are safer to use. They are less specific, but have minimal to no adverse effects.
AHCC: Benefits and Safety
by Megan Nunn 15/9/24 verywellhealth
In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says. When choosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.
AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections
by Judith A Smith 22/6/22 National Library of Medicine
To determine the efficacy, safety, and durability of the use of AHCC supplementation for 6 months to support the host immune system to clear high-risk human papillomavirus (HPV) infections. The AHCC supplement is a proprietary, standardized extract of cultured lentinula edodes mycelia (AHCC®, Amino Up, Ltd., Sapporo, Japan) that has been shown to have unique immune modulatory benefits.
HPV Eradicated by AHCC Supplement, Preclinical Study Suggests
In the study cervical cancer cells were treated with AHCC and incubated for 72 hours with sampling every 24 hours. The study was then repeated in two orthotopic mouse models, one HPV positive and other HPV negative control. The HPV expression was eradicated with once daily AHCC dosing for 90 days with durable response after 30 day observation off treatment. Smith then repeated the study to confirm findings and added sampling for correlative testing of immune markers to determine the mechanism by which AHCC eradicates the HPV virus.
AHCC: Should you take it for HPV and cervical dysplasia?
by Dr. Nick Targets HPV 2020 YouTube
The internet abounds with claims regarding the use of AHCC to eliminate HPV, but is it hype or money well spent? Dr. Nick LeRoy weighs in on whether AHCC is is founded in fact or mired in a misuse of your money! #ahcc
HPV eradicated by AHCC supplement, preclinical study suggests
According to the study, led by Dr. Judith A. Smith, treating cervical cancer cells with AHCC led to the eradication of HPV, as well as a decrease in the rate of tumor growth in vitro and in vivo, in research presented at the Society of Gynecological Oncology 45th Annual Meeting on Women’s Cancer in Tampa, Florida.
AHCC and HPV
Women who test positive for HPV are left in a limbo, as they are unable to treat or clear their bodies of HPV, whilst knowing they are at high risk for the development of cervical cancer. However, recent studies have explored how AHCC, a shiitake mushroom extract product, has the potential to help clear the body of HPV after diagnosis. Though studies are currently ongoing, it is a new light in the dark that has the potential to help women with HPV across the world.
AHCC HPV and other treatments for persistent HPV - which is best for you?
Most people (an estimated 80 per cent) will become infected with HPV within months to a few years after becoming sexually active. The majority will have no symptoms, and in most cases (90 per cent), HPV will be eliminated from the body within two years.
Japanese Mushroom Extract Could Help Treat HPV Infections
by Roxanne Nelson 31/10/14 MedScape
A Japanese mushroom extract, active hexose correlated compound (AHCC), appears to be effective in eradicating persistent human papillomavirus (HPV) infection, according to results of a small pilot study.
AHCC nutritional supplements to prevent HPV-associated cancers
The human papilloma virus (HPV) currently has no cure, with virtually all cases of cervical cancer being caused by HPV. Here, Judith Smith, PharmD, BCOP, CPHQ, FCCP, FISOPP, of UTHealth McGovern Medical School, Houston, TX, discusses her findings looking at the nutritional supplement active hexose correlated compound, more commonly known as AHCC, that has shown promise in eradicating HPV. Dr Smith was speaking from the 2018 Hematology/Oncology Pharmacy Association (HOPA) Annual Conference, held in Denver, CO.
Cervical Cancer
Hi! I am thinking about trying AHCC and just have a quick question about how long I should use it for. Do I just take the 3000mg of it daily for 6 months than stop? Will it harm me if I stop abruptly?
