Vitamin C
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Effect of vitamin C supplements on urinary oxalate and pH in calcium stone-forming patients
These data suggest that vitamin C supplementation may increase urinary oxalate excretion and the risk of calcium oxalate crystallization in calcium stone-forming patients.
The Vitamin C Myth
It was Noble Prize Winner Linus Pauling, a chemist, who really popularized vitamin C in the early 60s. He suggested that the vitamin, already known to protect against scurvy, was even more beneficial in mega doses. Dr. Marvin Lipman is an endocrinologist in New York and Chief Medical Advisor for the magazine Consumer Reports.
Sepsis Is A Global Killer. Can Vitamin C Be The Cure?
Every day, approximately 30,000 people die globally of sepsis. The condition comes about when your immune system overreacts to an infection, leading potentially to organ failure and death. There is no cure. But then in 2017, a doctor proposed a novel treatment for sepsis, a mixture that included Vitamin C, arguing it saved the lives of most of his patients. NPR's Richard Harris has been reporting on this treatment and how it's divided scientists from around the world.
Vitamin C 'gives chemotherapy a boost'
by Helen Briggs 9/2/14 BBC NEWS
Pharmaceutical companies are unlikely to run trials, as vitamins cannot be patented.
Vitamin C Fails Again As Treatment For Sepsis
Though attention has understandably been on COVID-19 over the last year, nearly as many people in the hospital have died with a different condition: sepsis. A study now casts doubt on a once-promising treatment for this disease.
How Linus Pauling duped America into believing vitamin C cures colds
by Megan Thielking 27/2/15 Vox
Vitamin C Apparently Not Useful For Sepsis After All
[https://www.npr.org/2021/02/23/970672328/vitamin-c-apparently-not-useful-for-sepsis-after-all by Richard Harris 23/2/21 npr]
The nation's attention has understandably been on COVID-19 over this past year. But in that same span of time, nearly as many people in the hospital have died with a different condition - sepsis. Researchers have been searching for better ways to treat this disease, which is sometimes called blood poisoning. A new study throws cold water on one treatment that had drawn a great deal of interest in the past few years. NPR science correspondent Richard Harris reports.
Dietitians say vitamin C supplements and drinks are a waste of money — eating the right vegetables is a more efficient way to stay healthy
by Allana Akhtar 11/7/22 BUSINESS INSIDER
But data and expert interviews suggest very few Americans need to take vitamin C supplements, particularly those that have far more milligrams than the daily recommendation. Even in cases where a diet could result in low vitamin C, experts told Insider not to rush to the supplement aisle, but rather eat more fruits and veggies.
5 reasons why you should add a vitamin C serum to your skincare routine, according to a dermatologist
by Toketemu Ohwovoriole 10/8/21 BUSINESS INSIDER
Vitamin C is an antioxidant that can benefit all skin types and is one of the best vitamins for your skin. It has numerous benefits, including helping with anti-aging and reversing some of the damage done to your skin by radiation from the sun.
Vitamin C, zinc don’t lessen Covid-19 symptoms, study finds
by Sandee LaMotte 12/2/21 CNN HEALTH
Despite the popular use of vitamin C and zinc to fight off or lessen the severity of viral colds and flu, the new study, published Friday in JAMA Network Open, found the two supplements were of no benefit to people isolating at home with Covid-19.
5 science-backed health benefits of vitamin C and how to add more to your diet
by Nina Bahadur 21/9/21 BUSINESS INSIDER
Vitamin C, also known as ascorbic acid, is used for various processes in the body including building bone, collagen, and muscles. It's also important for wound healing.
Controlling Gangrene; Blood-Starved Tissue Vitalized By Vitamin C and Histidine
This is a digitized version of an article from The Times’s print archive, before the start of online publication in 1996. To preserve these articles as they originally appeared, The Times does not alter, edit or update them.
Cortisone May Aid Arteriosclerosis By Storing Vitamin C in the Blood
by The New York Times 15/9/1950
Cortisone and ACTH may be effective against hardening of the arteries because they facilitate the storage of Vitamin C (ascorbic acid) in the blood and the adrenal glands, experiments reported at the opening of the American Physiological Society's summer meeting at Ohio State University here today indicated.
10 signs you might have a vitamin C deficiency, according to an expert
[https://africa.businessinsider.com/lifestyle/10-signs-you-might-have-a-vitamin-c-
Your body needs vitamin C to help heal wounds, keep your bones and teeth strong, and to help absorb iron in your body. Vitamin C is also used to help create vital proteins that are responsible for making your skin, tendons, ligaments, and blood vessels, according to the US National Library of Medicine . The body needs vitamin C to help a handful of enzymes in the body produce molecules we need every day, like collagen and carnitine.
Ascorbic Acid (Vitamin C)
THE discussion on ascorbic acid (vitamin C) which was held in Section B (Chemistry) at the recent meeting of the British Association was, as the official title of the discussion indicated, mainly devoted to the chemical aspect of the subject.
Association between vitamin C in serum and trouble sleeping based on NHANES 2017–2018
by Shihong Wang 27/4/24 scientific reports
Vitamin C is an important micronutrient for human. Association between vitamin C and trouble sleeping was less studied. Therefore, the purpose of this study was to investigate the possible link between vitamin C in serum and trouble sleeping.
The role of vitamin C in pneumonia and COVID-19 infection in adults with European ancestry: a Mendelian randomisation study
by European Journal of Clinical Nutrition 30/8/21 EJCN
Genetically predicted circulating levels of vitamin C was not associated with susceptibility to severe COVID-19, COVID-19 hospitalisation, any COVID-19 infection nor pneumonia. Similar results were obtained when a weighted median and MR-Egger methods were used.
Vitamin C epigenetically controls osteogenesis and bone mineralization
by Roman Thaler 6/10/22 nature communications
Vitamin C deficiency disrupts the integrity of connective tissues including bone. For decades this function has been primarily attributed to Vitamin C as a cofactor for collagen maturation. Here, we demonstrate that Vitamin C epigenetically orchestrates osteogenic differentiation and function by modulating chromatin accessibility and priming transcriptional activity.
Vitamin C and Carbohydrate Metabolism
by SACHCHIDANANDA BANERJEE 28/9/1940 nature
IT has been shown previously1,2 that deficiency of vitamin C in guinea pigs leads to a change in the carbohydrate metabolism as judged by (1) the glycosuria, (2) the diabetic type of the glucose tolerance curve, and (3) the depletion of the glycogen content of the liver. It has also been shown that the normal metabolism of carbohydrate is restored after the administration of vitamin C. From the above evidence, it has been suggested that the action of vitamin C is similar to that of insulin.
Supplies of Vitamin C
TATEMENTS have recently appeared in the German scientific press to the effect that German men of science have discovered that the hips of the wild rose are a rich source of the antiscorbutic vitamin C, and that the German State railways have arranged to grow wild roses along the tracks.
Apparent Vitamin C in Walnuts
by RONALD MELVILLE 16/10/1943 nature
THE remarkably high vitamin C content of walnuts has been mentioned by various workers1,2. Recent work3,4 indicates that foods may contain substances which react with the dye and are estimated as ascorbic acid under the usual titration conditions but are not true vitamin C.
Vitamin C exhibits pro-oxidant properties
by Ian D. Podmore 9/4/98 nature
Vitamin C is marketed as a dietary supplement, partly because of its ‘antioxidant’ properties. However, we report here that vitamin C administered as a dietary supplement to healthy humans exhibits a pro-oxidant, as well as an antioxidant, effect in vivo.
Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance
by Shoko Takisawa 20/3/19 scientific reports
L-Ascorbic acid (AsA) is a water-soluble antioxidant. We examined the effect of AsA deficiency on skeletal muscle using senescence marker protein-30 (SMP30)-knockout (KO) mice that are defective in AsA biosynthesis, which makes this mouse model similar to humans, to clarify the function of AsA in skeletal muscle. Eight-week-old female SMP30-KO mice were divided into the following two groups: an AsA-sufficient group [AsA(+)] that was administered 1.5 g/L AsA and an AsA-deficient group [AsA(−)] that was administered tap (AsA-free) water.
What The Heck Does Vitamin C Serum Do For Your Skin, Anyway?
by Brittany Nims 21/6/19 HUFFPOST
These days people are turning to Vitamin C to give their lackluster complexion a juicy glow. Sephora’s best Vitamin C serums promise results for dry skin, oily skin, acne scars, fine lines and wrinkles, and even dark spots and sun damage. Those are some big promises for small bottles.
Sorry, Your Vitamin C Megadose Is Basically Useless
[https://www.huffpost.com/entry/emergen-c-airborne-does-it-work_n_55f3709ee4b063ecbfa486c8 by Anna Almendrala 5/1/18 HUFFPOST]
To avoid a cold or cut one short, you may be tempted to stock up on supplemental drink mix-ins like Emergen-C and Airborne for supposed cold-fighting ingredients like vitamin C or zinc. But do these unregulated powders and tablets actually work?
by Jenna Birch 6/5/20 HUFFPOST
From the start of the coronavirus pandemic, there has been a focus on wellness, and ways to avoid becoming seriously ill. One of the methods people are relying on is taking vitamins targeted to bolstering immunity.
Turns Out Oranges Aren't The Best Source Of Vitamin C, After All
by Julie R. Thomson 6/1/17 HUFFPOST
It’s that time of year. The time of year when everyone around us is sick and all us healthy people are popping Emergen-Cs and vitamin C tablets in a desperate attempt to try to remain well. Here’s the thing you should know: despite the commonly held belief, vitamin C doesn’t actually help you fight a cold ― it took 50 years of research to conclude that.
On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence
by Jens Lykkesfeldt 6/20 ScienceDirect
For decades, the potential beneficial effect of vitamin C on human health—beyond that of preventing scurvy—has been subject of much controversy. Hundreds of articles have appeared either in support of increased vitamin C intake through diet or supplements or rejecting the hypothesis that increased intake of vitamin C or supplementation may influence morbidity and mortality.
The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19
by Ioannis Zabetakis 27/10/20 frontiers
From Pauling’s theories to the present, considerable understanding has been acquired of both the physiological role of vitamin C and of the impact of vitamin C supplementation on the health. Although it is well known that a balanced diet which satisfies the daily intake of vitamin C positively affects the immune system and reduces susceptibility to infections, available data do not support the theory that oral vitamin C supplements boost immunity.
The Mystery of Vitamin C
Also known as ascorbic acid, vitamin C is a small carbohydrate molecule first identified in the 1920s by Albert von Szent Györgyi, who discovered that it was able to prevent and cure scurvy. Scurvy is a pathological life-threatening condition suffered by people who do not have access to fruits or vegetables for long periods of time. A decade earlier, Kazimierz Funk had prepared a list of nutritional factors, called vitamins, whose deficiencies cause severe diseases in humans. In his list, Funk used the letter "C" to designate a factor still unidentified, but known to prevent scurvy. Later on, Szent Györgyi and Haworth chemically identified "C" as ascorbic acid, and named it so because ascorbic means "anti-scurvy." Over the next century, what we now know as vitamin C became one of the most popular drugs in human history.
by Bettina Moritz 11/20 ScienceDirect
Stress-related disorders, such as depression and anxiety, present marked deficits in behavioral and cognitive functions related to reward. These are highly prevalent disabling conditions with high social and economic costs.
Vitamin C Deficiency
Vitamin C deficiency, commonly called scurvy, is a well-documented nutritional disorder with historical significance that continues to impact global health today. Vitamin C is an essential nutrient for maintaining an individual's good health and well-being.
The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!
by Darius J.R. Lane 10/14 ScienceDirect
Ascorbate is a cofactor in numerous metabolic reactions. Humans cannot synthesize ascorbate owing to inactivation of the gene encoding the enzyme l-gulono-γ-lactone oxidase, which is essential for ascorbate synthesis.
Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids.
Vitamin C functions physiologically as a water-soluble antioxidant by virtue of its high reducing power. It is a cofactor for enzymes involved in the biosynthesis of collagen, carnitine, and neurotransmitters in vitro, and it can quench a variety of reactive oxygen species and reactive nitrogen species in aqueous environments.
Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans
by Carr Anitra C 6/99 ScienceDirect
The current recommended dietary allowance (RDA) for vitamin C for adult nonsmoking men and women is 60 mg/d, which is based on a mean requirement of 46 mg/d to prevent the deficiency disease scurvy. However, recent scientific evidence indicates that an increased intake of vitamin C is associated with a reduced risk of chronic diseases such as cancer, cardiovascular disease, and cataract, probably through antioxidant mechanisms.
Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability
by Amanda Costa Caritá M.D 2/20 ScienceDirect
Vitamin C (Vit C) is a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. However, the biggest challenge in the utilization of Vit C is to maintain its stability and improve its delivery to the active site. Several strategies have been developed such as: controlling the oxygen levels during formulation and storage, low pH, reduction of water content in the formulation and the addition of preservative agents. Additionally, the utilization of derivatives of Vit C and the development of micro and nanoencapsulated delivery systems have been highlighted. In this article, the multiple applications and mechanisms of action of vitamin C will be reviewed and discussed, as well as the new possibilities of delivery and improvement of stability.
Is vitamin C a booster of the effects of dietary nitrate on endothelial function? Physiologic rationale and implications for research
by Eazaz Lbban B.Sc. 5/23 ScienceDirect
Endothelial dysfunction (ED) is an early marker of vascular damage linked to the loss of integrity of the endothelial lining and represents a key step in the pathogenesis of atherosclerosis and cardiovascular diseases (CVDs). ED may be reversible, hence the development and testing of effective early interventions could be beneficial for the prevention and treatment of CVDs.
The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia
by Nianyi Li, MD, PhD 2/11/20 JAMA Network Open
Importance It remains uncertain whether vitamin C routinely used with oral iron supplements is essential for patients with iron deficiency anemia (IDA).
High-dose vitamin C: A promising anti-tumor agent, insight from mechanisms, clinical research, and challenges
by Hanzheng Zhao 27/6/25 ScienceDirect
Vitamin C, also known as ascorbic acid, has sparked controversy since it first emerged as a potential anti-cancer agent. However, an increasing number of preclinical studies have demonstrated that high-dose vitamin C exhibits selective anti-tumor effects, including "pro-oxidative cytotoxicity", "anti-cancer epigenetic regulation", and "immune modulation".
Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials
by Juraschek Stephen 5/12 ScienceDirect
Background: In observational studies, increased vitamin C intake, vitamin C supplementation, and higher blood concentrations of vitamin C are associated with lower blood pressure (BP). However, evidence for blood pressure–lowering effects of vitamin C in clinical trials is inconsistent.
Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
by Maira Di Tano 11/5/20 nature communications
Pharmacological doses of vitamin C (ascorbic acid) have been proposed as a potential anticancer therapy according to different pre-clinical and clinical trials1,2,3. Recent studies indicate that KRAS-mutant cancers may exhibit higher susceptibility to vitamin C antitumor effects, thus making this generally non-toxic compound a potential weapon against this aggressive tumor type4,5.
New Developments and Novel Therapeutic Perspectives for Vitamin C1,2
by Li Yi,Schellhorn Herb E. 10/07 ScienceDirect
Vitamin C is required for collagen synthesis and biosynthesis of certain hormones and recommended dietary intake levels are largely based these requirements. However, to function effectively as an antioxidant (or a pro-oxidant), relatively high levels of this vitamin must be maintained in the body. The instability of vitamin C combined with its relatively poor intestinal absorption and ready excretion from the body reduce physiological availability of this vitamin.
Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response
by Xiadi He 1 2 3, 3/4/25 ScienceDirect
Vitamin C (vitC) is essential for health and shows promise in treating diseases like cancer, yet its mechanisms remain elusive. Here, we report that vitC directly modifies lysine residues to form “vitcyl-lysine”—a process termed vitcylation.
Vitamin C
This sheet is about exposure to vitamin C in pregnancy and while breastfeeding. This information is based on available published research studies. It should not take the place of medical care and advice from your healthcare providers.
Stability of vitamin C in frozen raw fruit and vegetable homogenates
by Katherine M. Phillips 5/10 ScienceDirect
Retention of vitamin C in homogenized raw fruits and vegetables stored under routine conditions prior to analysis was investigated. Raw collard greens (Brassica oleracea var. viridis), clementines (Citrus clementina hort. ex Tanaka), and potatoes (Solanum tuberosum) were chosen, being representative of foods to be sampled in USDA's National Food and Nutrient Analysis Program (NFNAP), and having different expected stability of ascorbic acid (AA).
The roles of vitamin C in infectious diseases: A comprehensive review
by Liangchao Guan 6/25 ScienceDirect
Vitamin C is a versatile nutrient with essential antioxidant properties and roles in amino acid metabolism, collagen promotion, and hormone synthesis. It has long been regarded as benefitting infectious disease management, although its specific roles remain uncertain.
A comprehensive review and recent advances of vitamin C: Overview, functions, sources, applications, market survey and processes
by Xu Ze See 6/24 ScienceDirect
In this present era, humans have been shifting the general focus and exposure to alternatives or actions on sustaining precious resources which are namely the resource of environment and personal health (Godfrey and Richardson, 2002), which the focus of this review has a crucial relationship to human health.
Preharvest and postharvest factors influencing vitamin C content of horticultural crops
by Seung K. Lee 11/2000 ScienceDirect
Vitamin C, including ascorbic acid and dehydroascorbic acid, is one of the most important nutritional quality factors in many horticultural crops and has many biological activities in the human body. The content of vitamin C in fruits and vegetables can be influenced by various factors such as genotypic differences, preharvest climatic conditions and cultural practices, maturity and harvesting methods, and postharvest handling procedures.
Effect of vitamin C supplements on urinary oxalate and pH in calcium stone-forming patients
by Alessandra Calábria Baxmann 3/2000 ScienceDirect
Forty-seven adult calcium stone-forming patients received either 1 g (N = 23) or 2 g (N = 24) of vitamin C supplement for 3 days and 20 healthy subjects received 1 g. A 24-hour urine sample was obtained both before and after vitamin C for calcium, oxalate, magnesium, citrate, sodium, potassium, and creatinine determination. The Tiselius index was used as a calcium oxalate crystallization index. A spot fasting morning urine sample was also obtained to determine the urinary pH before and after vitamin C.
